منابع مشابه
Matrix metalloproteinases: a role in emphysema?
The combined observations that (1) an inherited deficiency activity was found to be most strongly related to smoking, confirming previous studies. Interestingly, there was no of the major serum neutrophil elastase inhibitor, a1-proquantitative relationship between the enzyme levels, loss teinase inhibitor (a1-PI; a1-antitrypsin) predisposes to deof lung function, or degree of emphysema. Since t...
متن کاملP 88: Matrix Metalloproteinases in Neuroinflammation
Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...
متن کاملMatrix metalloproteinases
What makes an MMP an MMP? They all have a conserved zinc-binding site in their catalytic domain (HEXGHXXGXXH), and the sequence PRCGVPD in the propeptide domain. The cysteine residue serves to anchor the propeptide to the catalytic zinc, suppressing enzymatic activity in a manner that is not unlike a thumb in an open mouth. Release of this interaction results in proteolytic activity. MMPs are a...
متن کاملMatrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs.
STUDY OBJECTIVE To evaluate the effect of CP-471,474 (Pfizer Global Research and Development; Groton, CT), a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) in an experimental model of emphysema. DESIGN Randomized, double-blinded, controlled experiment. SETTING Biochemistry and morphology laboratories and animal research facility. METHODS Guinea pigs were exposed to cigarette...
متن کاملEmphysema in Guinea Pigs Attenuates Tobacco Smoke-Induced Matrix Metalloproteinases Inhibition
2003;123;1633-1641 Chest Elizabeth M. Kudlacz, Peter G. Mitchell and Annie Pardo Moisés Selman, José Cisneros-Lira, Miguel Gaxiola, Remedios Ramírez, * Emphysema in Guinea Pigs Attenuates Tobacco Smoke-Induced Matrix Metalloproteinases Inhibition http://chestjournal.chestpubs.org/content/123/5/1633.full.html services can be found online on the World Wide Web at: The online version of this artic...
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ژورنال
عنوان ژورنال: Matrix Biology
سال: 2018
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2018.01.018